Impact of Magnesium on Oxytocin Receptor Function

Impact of Magnesium on Oxytocin Receptor Function

Blog Article

Background and Purpose: The intranasal administration of oxytocin (OT) reduces migraine headaches through activation of the oxytocin receptor (OTR).Magnesium ion Block of the Month Kits (Mg2+) concentration is critical to the activation of the OTR, and a low serum Mg2+ concentration is predictive of a migraine headache.We, therefore, examined the functional impact of Mg2+ concentration on OT-OTR binding efficacy using two complimentary bioassays.

Experimental Approach: Current clamp recordings of rat trigeminal ganglia (TG) neurons measured the impact of Mg2+ on an OT-induced reduction in excitability.In addition, we assessed the impact of Mg2+ on intranasal OT-induced craniofacial analgesia in rats.Key Results: While OT alone Chair dose-dependently hyperpolarized TG neurons, decreasing their excitability, the addition of 1.

75 mM Mg2+ significantly enhanced this effect.Similarly, while the intranasal application of OT produced dose-dependent craniofacial analgesia, Mg2+ significantly enhanced these effects.Conclusions and Implications: OT efficacy may be limited by low ambient Mg2+ levels.

The addition of Mg2+ to OT formulations may improve its efficacy in reducing headache pain as well as for other OT-dependent processes.